So thats a good thing, a positive thing
This evidence has inspired the ligandin model for vacuolar sequestration of anthocyanins ( 1 ), in which arGSTs are believed to protect the labile anthocyanidins ( 3 ) from degradation and/or guide them from their biosynthetic origin on the cytoplasmic surface of the endoplasmic reticulum to transporters located on the tonoplast membrane 18,19,31
In this process, depletion of large Fe-S clusters disrupts the electron transport chain, while the blockage of the tricarboxylic acid cycle further impairs mitochondrial energy metabolism, ultimately leading to cell death through proteotoxic stress and metabolic disruption (173)
As research on lactate and lactylation in cancer continues to flourish, strategies targeting lactate/lactylation have attracted significant interest as potential anticancer treatments
Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term
